Invitrogen
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:1,000 | - |
Immunohistochemistry (IHC) |
1:1,000 | View 1 publication 1 publication |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Non-human primate, Rat |
Published species |
Rat |
Host/Isotype |
Sheep / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthetic peptide from human Beclin-1 conjugated to blue carrier protein has been used as the antigen. |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Concentration |
Conc. Not Determined |
Storage buffer |
whole serum |
Contains |
no preservative |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
RRID |
AB_962043 |
Reconstitute with 150 µL of distilled water.
Centrifuge to remove any insoluble material.
The antigen is homologous in rat and mouse.
Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: APG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; Beclin-1-C 35 kDa; Beclin-1-C 37 kDa; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e
Gene Aliases: 4921513J16Rik; 5430417M23Rik; ATG6; beclin1; BECN1; GT197; VPS30
UniProt ID: (Human) Q14457, (Rat) Q91XJ1, (Mouse) O88597
Entrez Gene ID: (Human) 8678, (Rat) 114558, (Mouse) 56208
Molecular Function:
protease inhibitor
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