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Invitrogen

Bim Polyclonal Antibody

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Bim Polyclonal Antibody

Product Details

PA5-90693

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100-198 of human Bim (NP_6195271)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.35 mg/mL

Amount

335 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2806180

Product Specific Information

Positive Samples: Raji, Jurkat, 293T, HeLa, mouse spleen; Cellular Location: Endomembrane system, Mitochondrion, Peripheral membrane protein

Immunogen sequence: DTDRSPAPMS CDKSTQTPSP PCQAFNHYLS AMASMRQAEP ADMRPEIWIA QELRRIGDEF NAYYARRVFL NNYQAAEDHP RMVILRLLRY IVRLVWRMH

Target Information

BIM belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alternatively spliced; bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; Bcl-2 like 11; Bcl-2 related apoptotic gene product BimL; Bcl-2-like protein 11; bcl-2-related ovarian death agonist; Bcl-2-related ovarian death protein; Bcl2 interacting mediator of cell death; Bcl2-interacting mediator of cell death; Bcl2-L-11; BCL2-like 11 (apoptosis facilitator); BCL2L11; BH3 domain containing protein; Bim EL; Bim-A; Bim-alpha3; pro-apoptotic; Bim-alpha4; contains new exon; pro-apoptotic; Bim-alpha5; contains new exon; pro-apoptotic; BIM-alpha6; BIM-beta6; BIM-beta7; OTTHUMP00000197013; OTTHUMP00000204247; proapoptosis factor; Bim alpha 3; BLC2L11; proapoptosis factor; BimS; BCL2L11; proapoptotic BH-3; Bim splice variant; unnamed protein product

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Gene Aliases: 1500006F24Rik; BAM; bcl2-L-11; BCL2L11; BIM; BimL; BOD

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UniProt ID: (Human) O43521, (Mouse) O54918, (Rat) O88498

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Entrez Gene ID: (Human) 10018, (Mouse) 12125, (Rat) 64547

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Function(s)
protein binding microtubule binding protein kinase binding
Process(es)
in utero embryonic development leukocyte homeostasis B cell homeostasis B cell apoptotic process kidney development lymphocyte homeostasis myeloid cell homeostasis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cell-matrix adhesion spermatogenesis male gonad development intrinsic apoptotic signaling pathway in response to DNA damage post-embryonic development positive regulation of cell death mammary gland development positive regulation of protein homooligomerization response to endoplasmic reticulum stress tube formation odontogenesis of dentin-containing tooth regulation of apoptotic process T cell homeostasis positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of neuron apoptotic process ear development positive regulation of cell cycle regulation of organ growth developmental pigmentation regulation of developmental pigmentation spleen development thymus development post-embryonic organ morphogenesis positive regulation of apoptotic process by virus cellular process regulating host cell cycle in response to virus thymocyte apoptotic process positive regulation of release of cytochrome c from mitochondria extrinsic apoptotic signaling pathway in absence of ligand positive regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process involved in embryonic digit morphogenesis positive regulation of fibroblast apoptotic process positive regulation of intrinsic apoptotic signaling pathway meiosis I positive regulation of protein complex assembly lymphocyte apoptotic process positive regulation of lymphocyte apoptotic process T cell apoptotic process positive regulation of T cell apoptotic process cellular response to glucocorticoid stimulus positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of IRE1-mediated unfolded protein response brain development
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