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Bovine Lactoferrin Polyclonal Antibody, FITC

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Bovine Lactoferrin Polyclonal Antibody, FITC

Product Details

BLAC-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

Immunocytochemistry (ICC/IF)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-

Immunomicroscopy (IM)

1:50-1:200
-
Product Specifications

Species Reactivity

Bovine, Sheep

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Purified Bovine Lactoferrin protein.
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CKRX; iron binding protein; Kaliocin 1; Kaliocin1; Lactoferricin H; Lactoferrin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH

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Gene Aliases: Lf; LTF

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UniProt ID: (Bovine) P24627

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Entrez Gene ID: (Bovine) 280846, (Sheep) 554321

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Function(s)
lipopolysaccharide binding serine-type endopeptidase activity cysteine-type endopeptidase inhibitor activity receptor binding iron ion binding protein binding heparin binding protein serine/threonine kinase activator activity transfer/carrier protein
Process(es)
ossification regulation of cytokine production innate immune response in mucosa proteolysis ion transport antibacterial humoral response antifungal humoral response killing of cells of other organism negative regulation of lipopolysaccharide-mediated signaling pathway regulation of tumor necrosis factor production negative regulation of ATPase activity positive regulation of osteoblast proliferation positive regulation of toll-like receptor 4 signaling pathway negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation by host of viral process negative regulation of viral genome replication positive regulation of osteoblast differentiation defense response to Gram-negative bacterium positive regulation of NF-kappaB transcription factor activity membrane disruption in other organism iron ion homeostasis bone morphogenesis antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of protein serine/threonine kinase activity positive regulation of bone mineralization involved in bone maturation negative regulation of single-species biofilm formation in or on host organism positive regulation of chondrocyte proliferation negative regulation of cysteine-type endopeptidase activity negative regulation of tumor necrosis factor (ligand) superfamily member 11 production negative regulation of osteoclast development
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