Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: LEGDSSEDR AFRVRIAGDA PLQGVLGGAL TIPCHVHYLR PPPSRRAVLG SPRVKWTFLS RGREAEVLVA RGVRVKVNEA YRFRVALPTY PASLTDVSLA LNELRPNDSG IYRCEVQHGI DDSSDAVEVK VKGVVFLYRE GSARYAFSFS GAQEACARIG AHIATPEQLY AAYLGGYEQC DAGWLSDQTV RYPIQTPREA CYGDMDGFPG VRNYGVVDPD DLYDVYCYAE DLNGELFLGD PPEKLTLEEA RAYCQERGAE IATTGQLYAA WDGGLDHCSP GWLADGSVRY PIVTPSQRCG GGLPGVKTLF LFPNQTGFPN KHSRFNVY (23-350 aa encoded by BC010571 )
Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BEHAB; Brain-enriched hyaluronan-binding protein; brevican (brain specific proteoglycan in the aggrecan family); Brevican core protein; Chondroitin sulfate proteoglycan 7; chondroitin sulfate proteoglycan BEHAB
Gene Aliases: ALPBRE; BCAN; BEHAB; CSPG7; UNQ2525/PRO6018
UniProt ID: (Human) Q96GW7, (Rat) P55068, (Mouse) Q61361
Entrez Gene ID: (Human) 63827, (Rat) 25393, (Mouse) 12032
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