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Product Details
11414-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
C1QTNF3 Fusion Protein Ag1958 (118-246 aa encoded by BC016021) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.13 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: IAFMASLAT HFSNQNSGII FSSVETNIGN FFDVMTGRFG APVSGVYFFT FSMMKHEDVE EVYVYLMHNG NTVFSMYSYE MKGKSDTSSN HAVLKLAEGD EVWLRMGNGA LHGDHQRFST FAGFLLFETK (118-246 aa encoded by BC016021)
Target Information
Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Multiple isoforms of human CTRP3 have been reported. It has been suggested that CTRP3 may play a role in skeletal development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cartducin; cartonectin; Collagenous repeat-containing sequence 26 kDa protein; collagenous repeat-containing sequence of 26-kDa; Complement C1q tumor necrosis factor-related protein 3; CORS26; Secretory protein CORS26
Gene Aliases: 2310005P21Rik; C1ATNF3; C1QTNF3; CORCS; CORS; CORS-26; CORS26; CTRP3; UNQ753/PRO1484
UniProt ID: (Human) Q9BXJ4, (Mouse) Q9ES30
Entrez Gene ID: (Human) 114899, (Rat) 294806, (Mouse) 81799
negative regulation of gene expression
cellular triglyceride homeostasis
negative regulation of NF-kappaB import into nucleus
glucose homeostasis
fat cell differentiation
negative regulation of gluconeogenesis
positive regulation of cytokine secretion
negative regulation of inflammatory response
protein oligomerization
positive regulation of protein kinase B signaling
positive regulation of adiponectin secretion
protein trimerization
positive regulation of ERK1 and ERK2 cascade
negative regulation of monocyte chemotactic protein-1 production
negative regulation of interleukin-6 secretion
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