Sequence of this protein is as follows: GGQKAKMGNF PWQVFTNIHG RGGGALLGDR WILTAAHTLY PKEHEAQSNA SLDVFLGHTN VEELMKLGNH PIRRVSVHPD YRQDESYNFE GDIALLELEN SVTLGPNLLP ICLPDNDTFY DLGLMGYVSG FGVMEEKIAH DLRFVRLPVA NPQACENWLR GKNRMDVFSQ NMFCAGHPSL KQDACQGDSG GVFAVRDPNT DRWVATGIVS WGIGCSRGYG FYTKVLNYVD WIKKEMEEED
C1 component of human complement is a complex of three glycoproteins: C1q, C1r and C1s. C1r has a molecular weight of 83,000 and is present in plasma in an average concentration of 50 µg/ml, either as a complex with C1q and C1s or in the absence of C1q as a tetramer with C1s. The subcomponents of the C1 complex are responsible for the initiation of the classical pathway of complement activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Complement C1r subcomponent; Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain; Complement C1r-A subcomponent; Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain; Complement component 1 subcomponent r; Complement component 1 subcomponent r-A; complement component 1, r subcomponent; complement component 1, r-A subcomponent
Gene Aliases: AI132558; C1R; C1ra; mC1rA
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule