TWA1 was identified through a two hybrid-associated protein screen with RanBPM. TWA1 is well conserved through evolution and is localized within the nucleus. It interacts with RanBP9 and comprises a protein complex with RanBPM and Muskelin. TWA1 was found to possess the LisH-CTLH motif which is detected in proteins involved in microtubule dynamics, cell migration, nucleokinesis and chromosome segregation. These functions overlap with functions suggested for the RanGTPase cycle. Recent findings suggested that there is an as yet uncovered function of the RanGTPase cycle.
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Protein Aliases: BWK-1; Bwk1 leukemia-related; GID complex subunit 8 homolog; Glucose-induced degradation protein 8 homolog; protein C20orf11; protein C20orf11 homolog; Twa1; two hybrid associated protein 1; two hybrid associated protein No. 1 with RanBPM; Two hybrid-associated protein 1 with RanBPM
Gene Aliases: 2310003C23Rik; 4833420G11Rik; AI451474; Bwk1; C20orf11; GID8; TWA1
Molecular Function: scaffold/adaptor protein