This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster.
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Protein Aliases: C4b-binding protein alpha chain; C4BP; Proline-rich protein; PRP
Gene Aliases: C4BP; C4BPA; PRP
UniProt ID: (Human) P04003
Entrez Gene ID: (Human) 722