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Invitrogen
C4BPA Polyclonal Antibody
FIGURE: 1 / 5
C4BPA Antibody (PA5-42001) in WB
Western blot was performed using Anti-C4BPA Polyclonal Antibody (Product # PA5-42001) and bands corresponding to 93kDa and 52kDa of C4BPA were observed in the reported high expressing models- Hep G2, Mouse Epididymis, Mouse Liver, Rat Epididymis and Rat Liver in comparison to DU 145, U-937, BeWO and Mouse Lung . Whole cell extracts (30 µg lysate) of Hep G2 (Lane 1), DU 145 (Lane 2), U-937 (Lane 3), BeWO (Lane 4), tissue extracts (30ug lysate) of Mouse Lungs (Lane 4), Mouse Epididymis (Lane 5), Mouse Liver (Lane 6), Rat Epididymis (Lane 7) ... View More
Product Details
PA5-42001
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human C4BPA
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609765
Product Specific Information
Peptide sequence: QVLTGKRLMQ CLPNPEDVKM ALEVYKLSLE IEQLELQRDS ARQSTLDKEL
Sequence homology: Human: 100%
Target Information
There are 3 variants of Complement component 4 binding protein (C4bp), which is composed of alpha and beta chains. The predominant form is a 570 kDa complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. C4bp regulates the activation of the classical complement pathway. It is a cofactor to the C3b/C4b inactivator, crucial to the proteolytic cleavage of C4b and important in cleavage of C3b. C4bp also regulates the C4bC2a complex (C3 convertase), accelerating its degradation by dissociating the complement fragment C2a. Both the C4bp alpha and beta chains interact with anticoagulant protein S and C4bp alpha binds protein S. C4bp is expressed in the blood serum.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C4b-binding protein alpha chain; C4bp; Proline-rich protein; PRP; RP11-164O23.4
Gene Aliases: C4BP; C4BPA; PRP
UniProt ID: (Human) P04003
Entrez Gene ID: (Human) 722
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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