Sequence of this protein is as follows: SDEHCPELPP VDNSIFVAKE VEGQILGTYV CIKGYHLVGK KTLFCNASKE WDNTTTECRL GHCPDPVLVN GEFSSSGPVN VSDKITFMCN DHYILKGSNR SQCLEDHTWA PPFPICKSRD CDPPGNPVHG YFEGNNFTLG STISYYCEDR YYLVGVQEQQ CVDGEWSSAL PVCKLIQEAP KPECEKALLA FQESKNLCEA MENFMQQLKE SGMTMEELKY SLELKKAELK AKLL
Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide linked, multimeric protein that is composed of seven alpha chains and one beta chain. C4BP functions as a cofactor for C3beta inactivator in the cleavage of C3beta, and accelerates the decay of C4betaC2alpha (C3 convertase) by acting as a cofactor in the cleavage of C4beta by factor I. Streptococcal strains that express Ig-binding cell surface molecules, which are members of the M protein family, can bind to overlapping C4beta binding sites in C4BP and therefore, interfere with the classical pathway of complement activation. Bacteria-bound C4BP may be an evolved mechanism that downregulates complement activation in the bacterial host microenvironment, thereby reducing the occurrences of bacterial opsonization and phagocytosis.
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Protein Aliases: C4b-binding protein beta chain
Gene Aliases: C4BP; C4bp-ps1; C4BPB
UniProt ID: (Human) P20851