PA5-28017 targets C4 binding protein B in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28017 immunogen is recombinant fragment corresponding to a region within amino acids 18 and 252 of Human C4 binding protein B.
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This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
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Protein Aliases: C4b-binding protein beta chain; C4BP
Gene Aliases: C4BP; C4BPB
UniProt ID: (Human) P20851
Entrez Gene ID: (Human) 725