Proteintech

C6orf150 Polyclonal Antibody

C6orf150 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 5

C6orf150 Antibody (26416-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 26416-1-AP (C6orf150 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

C6orf150 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

26416-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:750-1:3000

View 30 publications 30 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 13 publications 13 publications

Immunoprecipitation (IP)

Assay-dependent

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

C6orf150 Fusion Protein Ag23455 (1-233 aa encoded by BC113608)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MQPWHGKAM QRASEAGATA PKASARNARG APMDPNESPA APEAALPKAG KFGPARKSGS RQKKSAPDTQ ERPPVRATGA RAKKAPQRAQ DTQPSDATSA PGAEGLEPPA AREPALSRAG SCRQRGARCS TKPRPPPGPW DVPSPGLPVS APILVRRDAA PGASKLRAVL EKLKLSRDDI STAAGMVKGV VDHLLLRLKC DSAFRGVGLL NTGSYYEHVK ISAPNEFDVM FKLE (1-233 aa encoded by BC113608)

Target Information

cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of 2', 5' phosphodiester linkage at the GpA step and the formation of 3', 5' phosphodiester linkage at the ApG step. This produces c[G(2',5')pA(3'5')p] responses. cGAS also binds cytosolic DNA directly, leading to the activation and synthesis of cGAMP. Then, a second messenger binds to and activates TMEM173/STING thereby triggering type-I interferon production. cGAS is also involved in innate immune sensorship of infection, detection of DNA from bacteria, response to cellular stress, DNA damage, and regulation of cellular senescence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury.

International journal of molecular sciences

Zhao J,Zhen N,Zhou Q,Lou J,Cui W,Zhang G,Tian B

Tue Mar 07 00:00:00 UTC 2023

cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.

Experimental neurology

Li B,Wang W,Li Y,Wang S,Liu H,Xia Z,Gao W,Zhao B

Sun Jan 01 00:00:00 UTC 2023

DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation.

Journal of medical virology

Lou M,Huang D,Zhou Z,Shi X,Wu M,Rui Y,Su J,Zheng W,Yu XF

Sun Jan 01 00:00:00 UTC 2023

Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Guan T,Li M,Song Y,Chen J,Tang J,Zhang C,Wen Y,Yang X,Huang L,Zhu Y,Wang H,Ding K,Zheng J,Zhang H,Liu T

Sat Apr 01 00:00:00 UTC 2023

FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.

Cellular signalling

Yu Z,Zheng L,Geng Y,Zhang Y,Wang Y,You G,Cai M,Li M,Cheng X,Zan J

Fri Sep 01 00:00:00 UTC 2023

Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Liu S,Gao X,Yin Y,Wang J,Dong K,Shi D,Wu X,Guo C

Sat Jul 01 00:00:00 UTC 2023

Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Liu S,Gao X,Yin Y,Wang J,Dong K,Shi D,Wu X,Guo C

Sat Jul 01 00:00:00 UTC 2023

Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Liu S,Gao X,Yin Y,Wang J,Dong K,Shi D,Wu X,Guo C

Sat Jul 01 00:00:00 UTC 2023

Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.

Cell death & disease

Li J,Sun Y,Zhao X,Ma Y,Xie Y,Liu S,Hui B,Shi X,Sun X,Zhang X

Sat Apr 08 00:00:00 UTC 2023

The role of chemerin in the regulation of cGAS-STING pathway in gestational diabetes mellitus placenta.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zhou X,Zhang H,Jiang Y,Wei L,Chen Y,Zhang J,Gao P,Zhu S,Fang C,Du Y,Su R,He M,Yu J,Wang S,Ding W,Feng L

Wed Mar 01 00:00:00 UTC 2023

TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.

Signal transduction and targeted therapy

Zheng W,Zhou Z,Rui Y,Ye R,Xia F,Guo F,Liu X,Su J,Lou M,Yu XF

Fri Feb 24 00:00:00 UTC 2023

Myricetin-Loaded Nanomicelles Protect against Cisplatin-Induced Acute Kidney Injury by Inhibiting the DNA Damage-cGAS-STING Signaling Pathway.

Molecular pharmaceutics

Qi X,Wang J,Fei F,Gao X,Wu X,Shi D,Guo C

Mon Jan 02 00:00:00 UTC 2023

Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.

Experimental lung research

Peng M,Li X,Zhang X,Peng L

Sat Dec 16 00:00:00 UTC 2023

Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.

Experimental lung research

Peng M,Li X,Zhang X,Peng L

Sat Dec 16 00:00:00 UTC 2023

Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.

Experimental lung research

Peng M,Li X,Zhang X,Peng L

Sat Dec 16 00:00:00 UTC 2023

Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.

Experimental lung research

Peng M,Li X,Zhang X,Peng L

Sat Dec 16 00:00:00 UTC 2023

Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.

Autophagy

Ma Z,Bai J,Jiang C,Zhu H,Liu D,Pan M,Wang X,Pi J,Jiang P,Liu X

Mon May 01 00:00:00 UTC 2023

STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.

Clinical immunology (Orlando, Fla.)

Sun Z,Liu H,Hu Y,Luo G,Yuan Z,Tu B,Ruan H,Li J,Fan C

Mon May 01 00:00:00 UTC 2023

STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.

Clinical immunology (Orlando, Fla.)

Sun Z,Liu H,Hu Y,Luo G,Yuan Z,Tu B,Ruan H,Li J,Fan C

Mon May 01 00:00:00 UTC 2023

Combination of STING agonist and CXCR3 antagonist disrupts immune tolerance to overcome anti-PD-L1 resistance in lung adenocarcinoma under oxidative stress.

Gene

Zhu L,Gao H,Huang S,Cao T,Zhai X,Hu J,Wang T,Dong J,Liu Z,Chen J,Liu J,Zhang Z,Zhou Q

Mon Jan 30 00:00:00 UTC 2023

Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.

Journal of ethnopharmacology

Qi J,Luo Q,Zhang Q,Wu M,Zhang L,Qin L,Xue Q,Nie X

Mon Jun 12 00:00:00 UTC 2023

Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.

Journal of neurology

Zhao X,Yu M,Zhao Y,Zheng Y,Meng L,Du K,Xie Z,Lv H,Zhang W,Liu J,Wang Q,Yuan Y,Wang Z,Deng J

Thu Sep 01 00:00:00 UTC 2022

Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.

Journal of neurology

Zhao X,Yu M,Zhao Y,Zheng Y,Meng L,Du K,Xie Z,Lv H,Zhang W,Liu J,Wang Q,Yuan Y,Wang Z,Deng J

Thu Sep 01 00:00:00 UTC 2022

Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.

Journal of clinical laboratory analysis

Zhou M,Cheng X,Zhu W,Jiang J,Zhu S,Wu X,Liu M,Fang Q

Sat Oct 01 00:00:00 UTC 2022

Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.

Oxidative medicine and cellular longevity

Bai L,Dai J,Xia Y,He K,Xue H,Guo Q,Tian D,Xiao L,Zhang X,Teng X,Wu Y,Jin S

Tue Aug 02 00:00:00 UTC 2022

Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.

Environmental pollution (Barking, Essex : 1987)

Shen R,Yang K,Cheng X,Guo C,Xing X,Sun H,Liu D,Liu X,Wang D

Sun May 01 00:00:00 UTC 2022

Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy.

Molecular neurobiology

Han C,Qian X,Ren X,Zhang S,Hu L,Li J,Huang Y,Huang R,Ooi K,Lin H,Xia C

Tue Nov 01 00:00:00 UTC 2022

Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection.

Journal of virology

Xu Y,Yang Q,Xue B,Wang X,Tian R,Deng R,Chen S,Wang X,Wang L,Wang C,Chen J,You R,Liu Q,Li H,Wang J,Li X,Liu S,Yang D,Tang S,Zhu H

Wed Apr 13 00:00:00 UTC 2022

PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Geng X,Zhang C,Li M,Wang J,Ji F,Feng H,Xing M,Li F,Zhang L,Li W,Chen Z,Hickson ID,Shen H,Ying S

Tue Mar 01 00:00:00 UTC 2022

PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Geng X,Zhang C,Li M,Wang J,Ji F,Feng H,Xing M,Li F,Zhang L,Li W,Chen Z,Hickson ID,Shen H,Ying S

Tue Mar 01 00:00:00 UTC 2022

Baicalein-loaded silk fibroin peptide nanofibers protect against cisplatin-induced acute kidney injury: Fabrication, characterization and mechanism.

International journal of pharmaceutics