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Product Details
25891-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Unconjugated
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: QYTTSYDPEL TESSGSASHI DCRMSPWSEW SQCDPCLRQM FRSRSIEVFG QFNGKRCTDA VGDRRQCVPT EPCEDAEDDC GNDFQCSTGR CIKMRLRCNG DNDCGDFSDE DDCESEPRPP CRDRVVEESE LARTAGYGIN ILGMDPLSTP FDNEFYNGLC NRDRDGNTLT YYRRPWNVAS LIYETKGEKN FRTEHYEEQI EAFKSIIQEK TSNFNAAISL KFTPTETNKA EQCCEETASS ISLHGKGSFR FSYSKNETYQ LFLSYSSKKE KMFLHVKGEI HLGRFVMRNR DV
Target Information
C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive. C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Complement component C9
Gene Aliases: ARMD15; C9; C9D
UniProt ID: (Human) P02748
Entrez Gene ID: (Human) 735
Performance Guarantee
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