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Invitrogen
CAB39 Polyclonal Antibody
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FIGURE: 1 / 3
CAB39 Antibody (PA5-102968) in IHC (P)
Immunohistochemistry analysis of CAB39 in rat muscle tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with CAB39 polyclonal antibody (Product # PA5-102968) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102968
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CAB39(Accession Q9Y376), corresponding to amino acid residues Q289-Q339.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CAB39.
Target Information
Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium binding protein, 39 kDa; Calcium-binding protein 39; MO25alpha; Protein Mo25; unnamed protein product
Gene Aliases: AA408805; AA960512; C78372; CAB39; CGI-66; MO25; MO25alpha
UniProt ID: (Human) Q9Y376, (Mouse) Q06138
Entrez Gene ID: (Human) 51719, (Mouse) 12283
signal transduction
response to activity
intracellular signal transduction
cellular hypotonic response
response to thyroid hormone
negative regulation of potassium ion transmembrane transport
positive regulation of peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
activation of protein kinase activity
positive regulation of peptidyl-serine phosphorylation
positive regulation of protein serine/threonine kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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