Immunogen sequence: SRGRLNSFTQ GILPIAFSRP TSQNYCSLEQ PGQGGSTSAF EQLQRSRRRL ISQRSSLETL EDIEENAPLR RCRTLSGSPR PKN
Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.