Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
19681-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:200-1:1,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Peptide |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.23 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Target Information
The expression of multiple classes of voltage dependent calcium channels (VDCCs) allows neurons to tailor calcium signaling to functionally discrete cellular regions. Although N-Type VDCCs exist before birth which is consistent with a role in migration, most N-Type VDCCs subunit expression is postnatal and is important in the genesis of synaptic transmission in discrete hippocampal fields.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BIII; Brain calcium channel III; calcium channel alpha12.2 subunit; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide isoform 5; calcium channel, voltage-dependent, L type, alpha 1B subunit; calcium channel, voltage-dependent, N type, alpha 1B subunit; Cav2.2 voltage-gated Ca2+ channel; voltage gated N-type calcium channel Ca(v)2.2; Voltage-dependent N-type calcium channel subunit alpha-1B; voltage-gated calcium channel alpha subunit Cav2.2; Voltage-gated calcium channel subunit alpha Cav2.2
Gene Aliases: alpha(1B); AW050276; AW060892; AW822256; BIII; CACH5; CACNA1B; CACNL1A5; CACNN; Cav2.2; Cchn1a; DYT23
UniProt ID: (Human) Q00975, (Mouse) O55017
Entrez Gene ID: (Human) 774, (Mouse) 12287, (Rat) 257648
Molecular Function:
voltage-gated ion channel
transport
chemical synaptic transmission
neurotransmitter secretion
locomotory behavior
regulation of heart contraction
regulation of blood pressure
regulation of ion transmembrane transport
response to pain
membrane depolarization
regulation of calcium ion transport
calcium ion transmembrane transport
membrane depolarization during action potential
positive regulation of neurotransmitter secretion
ion transport
calcium ion transport
response to organic cyclic compound
sensory perception of pain
response to testosterone
transmembrane transport
calcium ion import
response to ethanol
voltage-gated calcium channel activity
calcium channel activity
calcium ion binding
protein binding
ATP binding
protein C-terminus binding
high voltage-gated calcium channel activity
nucleotide binding
ion channel activity
voltage-gated ion channel activity
metal ion binding
protein phosphatase 2A binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support