Immunogen sequence: SCEDLPIPGT YHRGRNSGPN RAQGSWATPP QRGRLLYAPL LLVEEGAAGE GYLGRSSGPL RTFTCLHVPG THSDPSH
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
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Protein Aliases: AIED; calcium channel, voltage-dependent, L type, alpha 1F subunit; Cav1.4; CORDX3; CSNB2; CSNB2A; CSNBX2; JM8; JMC8; OA2; Voltage-dependent L-type calcium channel subunit alpha-1F; Voltage-gated calcium channel subunit alpha Cav1.4
Gene Aliases: AIED; CACNA1F; CACNAF1; Cav1.4; Cav1.4alpha1; COD3; COD4; CORDX; CORDX3; CSNB2; CSNB2A; CSNBX2; JM8; JMC8; OA2
UniProt ID: (Human) O60840
Entrez Gene ID: (Human) 778