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Invitrogen
CACNA2D1 Polyclonal Antibody
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CACNA2D1 Antibody (PA5-82359) in IHC (P)
Immunohistochemistry analysis of CACNA2D1 in human cerebellum, cerebral cortex, pancreas and skeletal muscle. Samples were incubated with CACNA2D1 polyclonal antibody (Product # PA5-82359). Shows similar protein distribution across tissues to independent CACNA2D1 antibody (Product # PA5-82340) (B).
Product Details
PA5-82359
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CACNA2D1. Recombinant protein control fragment (Product #RP-89931).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QFLLSLTFPR LLEAVEMEDD DFTASLSKQS CITEQTQYFF DNDSKSFSGV LDCGNCSRIF HGEKLMNTNL IFIMVESKGT CPCDTRLLIQ AEQTSDGPNP CDMVKQPRYR KGP
Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 92%.
Target Information
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium channel, L type, alpha 2 polypeptide; calcium channel, voltage-dependent, alpha 2/delta subunit 1; DHP; dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit; H_DJ0560O14.1; Voltage-dependent calcium channel subunit alpha-2/delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1; WUGSC:H_DJ0560O14.1
Gene Aliases: CACNA2; CACNA2D1; CACNL2A; CCHL2A; LINC01112; lncRNA-N3; MHS3
UniProt ID: (Human) P54289
Entrez Gene ID: (Human) 781
calcium ion transport
regulation of calcium ion transport
regulation of ventricular cardiac muscle cell membrane repolarization
calcium ion transport into cytosol
cardiac conduction
calcium ion transmembrane transport via high voltage-gated calcium channel
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
regulation of membrane repolarization during action potential
positive regulation of high voltage-gated calcium channel activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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