The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Synaptogyrins comprise a family of tyrosine-phosphorylated proteins with two neuronal (synaptogyrins 1 and 3) isoforms. Previous studies have indicated that synaptogyrins are involved in the regulation of neurotransmitter release. Synaptogyrin 1 is an integral membrane protein ubiquitously expressed in the nervous system. Synaptogyrin has four transmembrane domains and an extended cytoplasmic tail but it is not glycosylated. Synaptogyrin 1 is a tyrosine-phosphorylated by c-src and possibly other tyrosine kinases. The function of Synaptogyrin 1 is not well understood, but it may be a useful marker for nerve terminals and diagnosing neuroendocrine tumors.
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Protein Aliases: brain calcium channel beta 1 subunit; CAB1; CACNLB1; calcium channel beta 1 subunit; Calcium channel voltage-dependent subunit beta 1; calcium channel, L type, beta 1 polypeptide; calcium channel, voltage-dependent, beta 1 subunit; CCHLB1; dihydropyridine-sensitive L-type, calcium channel beta-1 subunit; voltage-dependent calcium channel beta1 subunit; Voltage-dependent L-type calcium channel subunit beta-1
Gene Aliases: CAB1; CACNB1; CACNLB1; Cchb1; CCHLB1