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Proteintech
CACNG1 Polyclonal Antibody
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Product Details
18389-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CACNG1 Fusion Protein Ag12918 (30-184 aa encoded by BC069493)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DHWAVLSPH MEHHNTTCEA AHFGLWRICT KRIPMDDSKT CGPITLPGEK NCSYFRHFNP GESSEIFEFT TQKEYSISAA AIAIFSLGFI ILGSLCVLLS LGKKRDYLLR PASMFYAFAG LCILVSVEVM RQSVKRMIDS EDTVWIEYYY SWSFAC (30-184 aa encoded by BC069493)
Target Information
Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an alpha1 subunit, a beta subunit, a gamma subunit and an alpha2 delta subunit. The beta subunit is encoded by four genes, designated beta1-beta4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the alpha1 subunit. L-type Ca ++ CP gamma1, also known as CACNLG or CACNG1, is a 222 amino acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, L-type Ca ++ CP gamma1 is a subunit of the dihydropyridine (DHP) sensitive calcium channel and may play a role in excitation-contraction coupling. L-type Ca++ CP gamma1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant disorder of skeletal muscle which manifests as a life-threatening hypermetabolic crisis triggered by commonly used inhalation anesthetics and depolarizing muscle relaxants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium channel, voltage-dependent, gamma subunit 1; Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma; L-type calcium channel gamma polypeptide; neuronal dihydropyridine-sensitive calcium channel gamma subunit; unnamed protein product; Voltage-dependent calcium channel gamma-1 subunit
Gene Aliases: CACNG1; CACNLG
UniProt ID: (Human) Q06432
Entrez Gene ID: (Human) 786
ion transport
calcium ion transport
ion transmembrane transport
positive regulation of muscle contraction
establishment of localization in cell
sarcoplasmic reticulum calcium ion transport
calcium ion transmembrane transport
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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