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Proteintech
CAD Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
16617-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CAD Fusion Protein Ag9912 (502-851 aa encoded by BC014178)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.32 mg/mL
Amount
48 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VAEPELMGT PDGTCYPPPP VPRQASPQNL GTPGLLHPQT SPLLHSLVGQ HILSVQQFTK DQMSHLFNVA HTLRMMVQKE RSLDILKGKV MASMFYEVST RTSSSFAAAM ARLGGAVLSF SEATSSVQKG ESLADSVQTM SCYADVVVLR HPQPGAVELA AKHCRRPVIN AGDGVGEHPT QALLDIFTIR EELGTVNGMT ITMVGDLKHG RTVHSLACLL TQYRVSLRYV APPSLRMPPT VRAFVASRGT KQEEFESIEE ALPDTDVLYM TRIQKERFGS TQEYEACFGQ FILTPHIMTR AKKKMVVMHP MPRVNEISVE VDSDPRAAYF RQAENGMYIR MALLATVLGR F (502-851 aa encoded by BC014178)
Target Information
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CAD trifunctional protein; carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase
Gene Aliases: CDG1Z; DEE50; EIEE50; GATD4
UniProt ID: (Human) P27708
Entrez Gene ID: (Human) 790
aspartate carbamoyltransferase activity
carbamoyl-phosphate synthase (ammonia) activity
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
dihydroorotase activity
glutaminase activity
protein kinase activity
protein binding
ATP binding
zinc ion binding
amino acid binding
carboxyl- or carbamoyltransferase activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
enzyme binding
identical protein binding
metal ion binding
aspartate binding
liver development
'de novo' pyrimidine nucleobase biosynthetic process
UDP biosynthetic process
UTP biosynthetic process
cellular amino acid metabolic process
glutamine metabolic process
glutamine catabolic process
phosphate-containing compound metabolic process
xenobiotic metabolic process
heart development
female pregnancy
lactation
response to amine
citrulline biosynthetic process
response to caffeine
organ regeneration
response to insulin
response to testosterone
response to starvation
'de novo' UMP biosynthetic process
'de novo' CTP biosynthetic process
pyrimidine nucleoside biosynthetic process
response to cortisol
nucleobase-containing small molecule metabolic process
cellular response to epidermal growth factor stimulus
cellular response to xenobiotic stimulus
pyrimidine-containing compound biosynthetic process
organophosphate biosynthetic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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