Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
CAD Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
16617-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CAD Fusion Protein Ag9912 (502-851 aa encoded by BC014178)
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VAEPELMGT PDGTCYPPPP VPRQASPQNL GTPGLLHPQT SPLLHSLVGQ HILSVQQFTK DQMSHLFNVA HTLRMMVQKE RSLDILKGKV MASMFYEVST RTSSSFAAAM ARLGGAVLSF SEATSSVQKG ESLADSVQTM SCYADVVVLR HPQPGAVELA AKHCRRPVIN AGDGVGEHPT QALLDIFTIR EELGTVNGMT ITMVGDLKHG RTVHSLACLL TQYRVSLRYV APPSLRMPPT VRAFVASRGT KQEEFESIEE ALPDTDVLYM TRIQKERFGS TQEYEACFGQ FILTPHIMTR AKKKMVVMHP MPRVNEISVE VDSDPRAAYF RQAENGMYIR MALLATVLGR F (502-851 aa encoded by BC014178)
Target Information
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CAD trifunctional protein; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; Multifunctional protein CAD
Gene Aliases: CAD; CDG1Z
UniProt ID: (Human) P27708
Entrez Gene ID: (Human) 790
aspartate carbamoyltransferase activity
carbamoyl-phosphate synthase (ammonia) activity
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
dihydroorotase activity
protein kinase activity
ATP binding
zinc ion binding
enzyme binding
identical protein binding
aspartate binding
hydrolase
ligase
urea cycle
liver development
'de novo' pyrimidine nucleobase biosynthetic process
UTP biosynthetic process
arginine biosynthetic process
glutamine metabolic process
heart development
female pregnancy
lactation
response to amine
drug metabolic process
peptidyl-threonine phosphorylation
response to caffeine
organ regeneration
response to testosterone
cellular response to drug
'de novo' UMP biosynthetic process
pyrimidine nucleoside biosynthetic process
protein autophosphorylation
response to cortisol
cellular response to epidermal growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support