Recommended positive controls: 293T, C2C12.
Predicted reactivity: Mouse (92%), Rat (92%), Bovine (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Aspartate carbamoyltransferase; CAD protein; CAD trifunctional protein; Dihydroorotase; Glutamine-dependent carbamoyl-phosphate synthase; multifunctional protein CAD
Gene Aliases: 2410008J01Rik; AU018859; CAD; CDG1Z; Cpad