This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
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Protein Aliases: Aspartate carbamoyltransferase; CAD protein; CAD trifunctional protein; cad-PA; cad-PB; cad-PC; carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase; carbamyl phosphatate synthetase 2; caudal; CG1759-PA; CG1759-PB; CG1759-PC; Dihydroorotase; Glutamine-dependent carbamoyl-phosphate synthase; Homeotic protein caudal; multifunctional protein CAD
Gene Aliases: 2410008J01Rik; 38E.19; anon-WO2004063362.83; AU018859; BOS_11933; CAD; cb456; cd; CDG1Z; CG1759; Cpad; Dmel\CG1759; Dmel_CG1759; S67; si:dkey-221h15.3; wu:fc30c12; wu:fc33d01; wu:fc67g02