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Proteintech
CADM3 Polyclonal Antibody
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Product Details
15660-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CADM3 Fusion Protein Ag8081 (1-398 aa encoded by BC033819)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGAPAASLL LLLLLFACCW APGGANLSQD DSQPWTSDET VVAGGTVVLK CQVKDHEDSS LQWSNPAQQT LYFGEKRALR DNRIQLVTST PHELSISISN VALADEGEYT CSIFTMPVRT AKSLVTVLGI PQKPIITGYK SSLREKDTAT LNCQSSGSKP AARLTWRKGD QELHGEPTRI QEDPNGKTFT VSSSVTFQVT REDDGASIVC SVNHESLKGA DRSTSQRIEV LYTPTAMIRP DPPHPREGQK LLLHCEGRGN PVPQQYLWEK EGSVPPLKMT QESALIFPFL NKSDSGTYGC TATSNMGSYK AYYTLNVNDP SPVPSSSSTY HAIIGGIVAF IVFLLLIMLI FLGHYLIRHK GTYLTHEAKG SDDAPDADTA IINAEGGQSG GDDKKEYFI (1-398 aa encoded by BC033819 )
Target Information
Cell adhesion molecule 3 (CADM3), also known as Necl-1, is a gene located on chromosome 1p36.22, encoding a protein that is part of the immunoglobulin superfamily involved in cell-cell adhesion processes. CADM3 is predominantly expressed in the nervous system, particularly in regions such as the brain and spinal cord, where it plays crucial roles in neuronal communication, synapse formation, and maintenance of neural network architecture. The protein functions by mediating homophilic and heterophilic interactions with other cell adhesion molecules, facilitating synapse stabilization and neuronal differentiation. CADM3's activity is essential for proper neural development and function, and dysregulation of its expression has been linked to various neurological disorders. Beyond its role in the nervous system, CADM3 also contributes to tumor suppression in certain cancers, as its expression is often downregulated in tumor tissues. Research into CADM3 continues to explore its potential as a therapeutic target in both neurobiology and oncology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BIgR; Brain immunoglobulin receptor; Cell adhesion molecule 3; IgSF4B; Immunoglobulin superfamily member 4B; immunoglobulin superfamily, member 4B; NECL-1; Nectin-like protein 1; nectin-lke 1; Synaptic cell adhesion molecule 3; SynCAM3; TSLC1-like 1; TSLC1-like protein 1; TSLL1; TSLL1; transmembrane protein; unnamed protein product
Gene Aliases: BIgR; CADM3; CMT2FF; IGSF4B; Necl-1; NECL1; SYNCAM3; TSLL1; UNQ225/PRO258
UniProt ID: (Human) Q8N126, (Mouse) Q99N28, (Rat) Q1WIM3
Entrez Gene ID: (Human) 57863, (Mouse) 94332, (Rat) 360882
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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