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Invitrogen
CADM3 Polyclonal Antibody
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FIGURE: 1 / 6
CADM3 Antibody (PA5-101295) in ICC/IF
Immunofluorescent analysis of CADM3 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C) incubated with CADM3 polyclonal antibody (Product # PA5-101295) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 at a dilution of 1:600.
Product Details
PA5-101295
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CADM3(Accession Q8N126), corresponding to amino acid residues E144-V194.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CADM3.
Target Information
Cell adhesion molecule 3 (CADM3), also known as Necl-1, is a gene located on chromosome 1p36.22, encoding a protein that is part of the immunoglobulin superfamily involved in cell-cell adhesion processes. CADM3 is predominantly expressed in the nervous system, particularly in regions such as the brain and spinal cord, where it plays crucial roles in neuronal communication, synapse formation, and maintenance of neural network architecture. The protein functions by mediating homophilic and heterophilic interactions with other cell adhesion molecules, facilitating synapse stabilization and neuronal differentiation. CADM3's activity is essential for proper neural development and function, and dysregulation of its expression has been linked to various neurological disorders. Beyond its role in the nervous system, CADM3 also contributes to tumor suppression in certain cancers, as its expression is often downregulated in tumor tissues. Research into CADM3 continues to explore its potential as a therapeutic target in both neurobiology and oncology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Brain immunoglobulin receptor; Cell adhesion molecule 3; dendritic cell nectin-like protein 1 short isoform; IgSF4B; Immunoglobulin superfamily member 4B; immunoglobulin superfamily, member 4B; NECL-1; nectin-like 1; Nectin-like protein 1; nectin-lke 1; Synaptic cell adhesion molecule 3; SynCAM3; TSLC1-like 1; TSLC1-like protein 1; TSLL1
Gene Aliases: BIgR; CADM3; IGSF4B; Necl-1; NECL1; SYNCAM3; TSLL1; UNQ225/PRO258
UniProt ID: (Human) Q8N126, (Mouse) Q99N28, (Rat) Q1WIM3
Entrez Gene ID: (Human) 57863, (Mouse) 94332, (Rat) 360882
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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