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Proteintech
CALCR Polyclonal Antibody
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Product Details
20868-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CALCR Fusion Protein Ag14920
Conjugate
Form
Liquid
Concentration
400 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
The Calcitonin Receptor inhibits bone resorption. This receptor is expressed during development and is involved in morphogenesis. Three alternatively spliced Calcitonin Receptor isoforms have been identified. In addition to binding calcitonin, the Calcitonin Receptor can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes. The Calcitonin Receptor has been reported in artery, blood, bone, brain, kidney, lung, placenta, prostate, skeletal muscle, and thyroid. ESTs have been isolated from bone, embryo, kidney, and melanocyte/uterus/fetal heart libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Calcitonin receptor; COPT1; CT receptor; CT-R; hCTR1
Gene Aliases: CALCR; Clr; CRT; CT-R; CTR; CTR1
UniProt ID: (Human) P30988, (Mouse) Q60755
Entrez Gene ID: (Human) 799, (Mouse) 12311
cell surface receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
protein transport
positive regulation of cAMP biosynthetic process
receptor internalization
positive regulation of adenylate cyclase activity
response to glucocorticoid
protein localization to plasma membrane
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
negative regulation of ossification
osteoclast differentiation
regulation of mRNA stability
regulation of bone resorption
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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