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Rockland
CALHM1 Polyclonal Antibody
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FIGURE: 1 / 3
CALHM1 Antibody (600-401-AA7) in ICC/IF
Immunofluorescence Microscopy of CALHM1 antibody. Tissue: Rat liver cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: CALHM1 antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: CALHM1 is a membrane protein. Staining: CALHM1 as red fluorescent signal.
Product Details
600-401-AA7
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-CALHM1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide near the N-terminus of human CALHM1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium homeostasis modulator protein 1; family with sequence similarity 26, member C; Protein FAM26C
Gene Aliases: CALHM1; EG546729; FAM26C; RGD1564891
UniProt ID: (Human) Q8IU99, (Mouse) D3Z291
Entrez Gene ID: (Human) 255022, (Rat) 499367, (Mouse) 546729
cation transport
ATP transport
regulation of ion transmembrane transport
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
protein homooligomerization
calcium ion transmembrane transport
ion transmembrane transport
cation transmembrane transport
transport
ion transport
calcium ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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