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Invitrogen
CALHM1 Polyclonal Antibody
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Product Details
PA5-53779
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CALHM1. Recombinant protein control fragment (Product #RP-91132).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CTEHAKAFAK VCIQQFFEAM NHDLELGHTH GTLATAPASA AAPTTPDGAE EEREKLRGIT DQGTMNRLLT SWHKCKPPLR LGQEEPPLMG NGW
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 80%.
Target Information
Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium homeostasis modulator protein 1; family with sequence similarity 26, member C; Protein FAM26C
Gene Aliases: CALHM1; FAM26C
UniProt ID: (Human) Q8IU99
Entrez Gene ID: (Human) 255022
ion transport
cation transport
calcium ion transport
ATP transport
ion transmembrane transport
regulation of ion transmembrane transport
sensory perception of taste
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
protein homooligomerization
protein heterooligomerization
calcium ion transmembrane transport
ATP export
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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