Immunogen sequence: CTEHAKAFAK VCIQQFFEAM NHDLELGHTH GTLATAPASA AAPTTPDGAE EEREKLRGIT DQGTMNRLLT SWHKCKPPLR LGQEEPPLMG NGW
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 80%.
Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.
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Protein Aliases: Calcium homeostasis modulator protein 1; family with sequence similarity 26, member C; Protein FAM26C
Gene Aliases: CALHM1; FAM26C
UniProt ID: (Human) Q8IU99
Entrez Gene ID: (Human) 255022