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Bethyl Laboratories
CAP-H2 Polyclonal Antibody
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Product Details
A302-275A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 425 and 475 of human chromosome-associated protein H2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
Structural maintenance of chromosomes (SMC) and non-SMC condensin proteins associate into complexes that have been implicated in the process of chromosome condensation. A crucial prerequisite for accurate segregation of replicated sister chromatids is the condensation of the chromosomes into a manageable form prior to metaphase. The condensin I complex consists of two SMC subunits, SMC2 and SMC4, and three non-SMC subunits, CAP-H, CAP-G, and CAP-D2. An alternative complex, the condensin II complex, contains alternate non-SMC subunits, CAP-G2, CAP-H2, and CAP-D3. CAP-H2 is also known as Non-SMC condensin II complex, subunit H2 (NCAPH2) or kleisin beta isoform 2. The three non-SMC subunits in the condensing complexes form a regulatory subcomplex that is required to activate the SMC ATPases and to promote mitosis-specific chromatin binding of the holocomplex. The precise individual functions of each non-SMC protein in activation remain to be determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAP-H2 subunit of the condensin II complex; Chromosome-associated protein H2; Condensin-2 complex subunit H2; CTA-384D8.36; Em:U62317.2; hCAP-H2; kleisin beta; Kleisin-beta; Non-SMC condensin II complex subunit H2; unnamed protein product
Gene Aliases: CAPH2; NCAPH2
UniProt ID: (Human) Q6IBW4
Entrez Gene ID: (Human) 29781
mitotic chromosome condensation
female meiotic division
meiotic chromosome condensation
chromosome condensation
T cell differentiation in thymus
mitotic sister chromatid separation
female meiosis chromosome separation
positive regulation of chromosome segregation
positive regulation of chromosome separation
positive regulation of chromosome condensation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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