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This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed, but have not been fully described.
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Protein Aliases: Actin regulatory protein CAP-G; actin-capping protein GCAP39; actin-regulatory protein CAP-G; capping protein (actin filament), gelsolin-like; epididymis secretory protein Li 66; gelsolin-like capping protein; macrophage capping protein; Macrophage-capping protein; myc basic motif homolog 1
Gene Aliases: AFCP; CAPG; gCap39; HEL-S-66; mbh1; MCP
Molecular Function: non-motor actin binding protein