Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).
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Protein Aliases: Ca++-dependent secretion activator; Ca2+ dependent secretion activator; Ca2+-dependent activator protein for secretion; Ca2+-dependent secretion activator; Ca2+-regulated cytoskeletal protein; CADPS1, CAPS, CAPS1, KIAA1121, CAPS-1; Calcium-dependent activator protein for secretion 1; Calcium-dependent secretion activator 1; CAPS-1
Gene Aliases: CADPS; CADPS1; CAPS; CAPS1; KIAA1121; UNC-31
UniProt ID: (Human) Q9ULU8
Entrez Gene ID: (Human) 8618
Molecular Function: calcium-binding protein