Immunogen sequence: MASDMIESCV KRTRIAFEVK LQKTSRSTDF RVPQSICTMF NVMVDAKAQS TKLCSMEMGQ EHQYHSKIDE LIEETVKEMI T; Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell junction, Cytoplasmic side, Cytoplasmic vesicle membrane, Peripheral membrane protein, synapse
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.
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Protein Aliases: Ca2+-dependent activator protein; Ca2+-dependent activator protein for secretion; Ca2+-dependent secretion activator; Ca<2+-dependent activator protein for secretion; Ca<2+>dependent activator protein for secretion; Calcium-dependent activator protein for secretion 1; Calcium-dependent secretion activator 1; CAPS-1; rCAPS
Gene Aliases: AU067781; Cadps; CAPS; CAPS1; Caps2; Kiaa1121; mKIAA1121
Molecular Function: calcium-binding protein