Search
Proteintech
CARD10 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
32374-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CARD10 fusion protein Ag36178
Conjugate
Form
Liquid
Concentration
600 µg/mL
Amount
90 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: ELQWAEELRD QYLQEMEDLR LKHRTLQKDC DLYKHRMATV LAQLEEIEKE RDQAIQSRDR IQLQYSQSLI EKDQYRKQVR GLEAERDELL TTLTSLEGTK ALLEVQLQRA QGGTCLKACA SSHSLCSNLS STWSLSEFPS PLGGPEATGE AAVMGGPEPH NSEEATDSEK EINRLSILPF PPSAGSILRR QREEDPAPPK RSFSSMSDIT GSVTLKPWSP GLSSSSSSDS VWPLGKPEGL LARGCGLDFL NRSLAIRVSG RSPPGGPEPQ DKGPDGLSFY GDRWSGAV
Target Information
CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-Kappa-B activation. When expressed in cells, this protein binds to BCL10 and activates NF-Kappa-B Recent experiments have shown that CARMA3 is required for EGF-induced NF-Kappa-B activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Bcl10 binding protein and activator of NFKB; CARD-containing MAGUK 3 protein; CARD-containing MAGUK protein 3; CARD10; CARD/MAGUK family member; Carma 3; Caspase recruitment domain-containing protein 10; unnamed protein product
Gene Aliases: BIMP1; CARD10; CARMA3; IMD89
UniProt ID: (Human) Q9BWT7
Entrez Gene ID: (Human) 29775
activation of NF-kappaB-inducing kinase activity
positive regulation of macromolecule metabolic process
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of immune response
protein-containing complex assembly
negative regulation of cell migration involved in sprouting angiogenesis
positive regulation of protein localization to nucleus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support