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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 341 and 630 of Human CARD10|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||Assay-dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29261 targets CARD10 in IHC(P), IHC(F), and WB applications and shows reactivity with Human and mouse samples.
The PA5-29261 immunogen is recombinant fragment corresponding to a region within amino acids 341 and 630 of Human CARD10.
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bcl10 binding protein and activator of NFKB; bcl10-interacting MAGUK protein 1; BIMP1; CARD-containing MAGUK 3 protein; CARD-containing MAGUK protein 3; carma 3; CARMA3; caspase recruitment domain family, member 10; caspase recruitment domain-containing protein 10
AI449026; BIMP1; CARD10; CARMA3