Immunogen sequence: DTMYQDRHE WLCARVDPFT DHDLDMGTIP SYSRAQQLLL VKLQRLMHRG SREEVDGTHH TLRALRNTLQ PEEALSTSDP RVSPRLSRAS FLFGQLLQFV SRSENKYKRM NSNERVRIIS GSPLGSLARS SLDATKLLTE KQEELDPESE LGKNLSLIPY SLVRAFYCER RRPVLFTPTV LAKTLVQRLL NSGGAMEFTI CKSDIVTRDE FLRRQKTETI IYSREKNPNA FECIAPANIE AVAAKNKHCL LEAGIGCTRD LIKSNIYPIV LFIRVCEKNI KRFRKLLPRP ETEEEFLRVC RLKEKELEAL PCLYATVEPD MWGSVEELLR VVKDKIGEEQ RKTIWVDEDQ L (805-1154 aa encoded by BC111719)
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
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Protein Aliases: bcl10-interacting maguk protein 3; CARD-containing MAGUK protein 1; Carma 1; caspase recruitment domain family, member 11; Caspase recruitment domain-containing protein 11; MGC133069
Gene Aliases: 0610008L17Rik; 2410011D02Rik; BENTA; BIMP3; CARD11; CARMA1; IMD11; PPBL