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Product Details
PA5-18145
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (QRKTIWVDEDQL) corresponding to the C-terminus amino acids of CARD11
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_10985634
Product Specific Information
This antibody is predicted to react with bovine, canine and mouse based on sequence homology.
Target Information
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bcl10-interacting maguk protein 3; CARD-containing MAGUK protein 1; Carma 1; caspase recruitment domain family, member 11; Caspase recruitment domain-containing protein 11; MGC133069
Gene Aliases: BENTA; BIMP3; CARD11; CARMA1; IMD11; PPBL
UniProt ID: (Human) Q9BXL7
Entrez Gene ID: (Human) 84433
positive regulation of cytokine production
stimulatory C-type lectin receptor signaling pathway
positive regulation of B cell proliferation
T cell costimulation
Fc-epsilon receptor signaling pathway
positive regulation of T cell proliferation
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
thymic T cell selection
positive regulation of interleukin-2 biosynthetic process
regulation of B cell differentiation
regulation of T cell differentiation
GMP metabolic process
GDP metabolic process
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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