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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.5-2 µg/mL | - |
Immunohistochemistry (IHC) |
10 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Mouse, Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.02% sodium azide |
Storage conditions |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C |
RRID |
AB_11154116 |
In Western blot applications, this antibody detects a band at ~125kDa. A suggested positive control is mouse thymus tissue lysate.
PA5-20032 can be used with blocking peptide PEP-0151.
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bcl10-interacting maguk protein 3; CARD-containing MAGUK protein 1; Carma 1; caspase recruitment domain family, member 11; Caspase recruitment domain-containing protein 11; MGC133069
Gene Aliases: 0610008L17Rik; 2410011D02Rik; BENTA; BIMP3; CARD11; CARMA1; IMD11; PPBL
UniProt ID: (Human) Q9BXL7, (Mouse) Q8CIS0
Entrez Gene ID: (Human) 84433, (Mouse) 108723
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