PA5-29702 targets CARD11 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29702 immunogen is recombinant fragment corresponding to a region within amino acids 25 and 275 of Human CARD11.
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The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
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Protein Aliases: bcl10-interacting maguk protein 3; BIMP3; CARD-containing MAGUK protein 1; card-maguk protein 1; Carma 1; CARMA1; caspase recruitment domain family, member 11; Caspase recruitment domain-containing protein 11
Gene Aliases: 0610008L17Rik; 2410011D02Rik; BENTA; BIMP3; CARD11; CARMA1; IMD11; PPBL