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Proteintech
CARD14 Polyclonal Antibody
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Product Details
28373-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CARD14 fusion protein Ag28969
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
90 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SLAEKDILEQ SLDEARGSRQ ELVERIHSLR ERAVAAERQR EQYWEEKEQT LLQFQKSKMA CQLYREKVNA LQAQVCELQK ERDQAYSARD SAQREISQSL VEKDSLRRQV FELTDQVCEL RTQLRQLQAE PPGVLKQEAR TREPCPREKQ RLVRMHAICP RDDSDCSLVS STESQLLSDL SATSSRELVD SFRSSSPAPP SQQSLYKRVA EDFGEEPWSF SSCLEIPEGD PGALPGAKAG DPHLDYELLD TADLPQLESS LQPVSPGRLD VSESGVLMRR RPARRIL
Target Information
Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3) and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14. CARD 14 is a 1,004 amino acid protein consisting of an N-terminal CARD domain, a central coiled-coil domain and a C-terminal tripartite domain comprised of a PDZ domain, an Src homology 3 domain and a GUK domain with homology to guanylate kinase. CARD 14 is expressed in the placenta where it positively regulates apoptosis. CARD 14 also controls NF-kappaB activation by phosphorylating BCL10, a signaling protein that activates NF-kappaB through the I kappaB kinase complex. Epigallocatechin-3-gallate (EGCG) is a polyphenol that induces the expression of CARD 14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bcl10-interacting maguk protein 2; CARD-containing MAGUK protein 2; CARD14; CARD/MAGUK family member; Carma 2; Caspase recruitment domain-containing protein 14; scaffold protein; unnamed protein product
Gene Aliases: BIMP2; CARD14; CARMA2; PRP; PSORS2; PSS1
UniProt ID: (Human) Q9BXL6
Entrez Gene ID: (Human) 79092
positive regulation of protein phosphorylation
apoptotic process
activation of NF-kappaB-inducing kinase activity
positive regulation of macromolecule metabolic process
tumor necrosis factor-mediated signaling pathway
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of immune response
positive regulation of NF-kappaB transcription factor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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