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Proteintech
CARMIL Polyclonal Antibody
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Product Details
27133-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CARMIL Fusion Protein Ag25876 (1021-1365 aa encoded by BC140770)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Amount
64.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RVDEGVDEF FTKKVTKMDS KKWSTRGSES HELNEGGDEK KKRDSRKSSG FLNLIKSRSK SERPPTILMT EEPSSPKGAV RSPPVDCPRK DTKAAEHNGN SERIEEIKTP DSFEESQGEE IGKVERSDSK SSPQAGRRYG VQVMGSGLLA EMKAKQEKRA ACAQKKLGND AVSQDSSSPA LSSVERSDGG GAGLPENRFG LGTPEKNTKA EPKAEAGSRS RSSSSTPTSP KPLLQSPKPS LAARPVIPQK PRTASRPDDI PDSPSSPKVA LLPPVLKKVP SDKERDGQSS PQPSPRTFSQ EVSRRSWGQQ AQEYQEQKQR SSSKDGHQGS KSNDSGEEAE KEFIFV (1021-1365 aa encoded by BC140770)
Target Information
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Capping protein regulator and myosin 1 linker protein 1; Capping protein, Arp2/3 and myosin-I linker homolog 1; Capping protein, Arp2/3 and myosin-I linker protein 1; capping protein, Arp2/3, and Myosin-I Linker homolog 1; CARMIL homolog; cytoskeleton protein; F-actin-uncapping protein LRRC16A; leucine rich repeat containing 16; leucine rich repeat containing 16A; Leucine-rich repeat-containing protein 16A; testicular tissue protein Li 107; unnamed protein product
Gene Aliases: CARMIL; CARMIL1; CARMIL1a; dJ501N12.1; dJ501N12.5; LRRC16; LRRC16A
UniProt ID: (Human) Q5VZK9
Entrez Gene ID: (Human) 55604
actin filament organization
cell migration
lamellipodium assembly
positive regulation of cell migration
positive regulation of actin filament polymerization
ruffle organization
regulation of Arp2/3 complex-mediated actin nucleation
macropinocytosis
urate metabolic process
positive regulation of stress fiber assembly
barbed-end actin filament uncapping
actin filament network formation
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of lamellipodium organization
negative regulation of barbed-end actin filament capping
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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