Immunogen sequence: ILRAPVDITG QFEKWGEEEA ELNKNFYDKK TAIHKALCDN VDTRTVMEEM RALVSQCNLY MAARKAVRKR PNQALLENIA LYLTHMLKIF GAVEEDSSLG FPVGGPGTSL SLEATVMPYL QVLSEFREGV RKIAREQKVP EILQLSDALR DNILPELGVR FEDHEGLPTV VKLVDRNTLL KEREEKRRVE EEKRKKKEEA ARRKQEQEAA KLAKMKIPPS EMFLSETDKY SKFDENGLPT HDMEGKELSK GQAKKLKKLF EAQEKLYKEY LQMAQNGSFQ; Positive Samples: HeLa, MCF7, Mouse liver; Cellular Location: Cytoplasm
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CysRS; cysteine translase; cysteine tRNA ligase 1, cytoplasmic; Cysteine--tRNA ligase, cytoplasmic; Cysteinyl-tRNA synthetase; cysteinyl-tRNA synthetase, cytoplasmic
Gene Aliases: CA3; CARS; CARS1; CYSRS; MGC:11246