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CASC5 Polyclonal Antibody
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FIGURE: 1 / 1
CASC5 Antibody (BS-5959R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Mouse testis; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with CASC5 Polyclonal Antibody, Unconjugated (bs-5959R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody for 20 minu... View More
Product Details
BS-5959R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CASC5, amino acids 2251-2342.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AF15q14; ALL1-fused gene from chromosome 15q14 protein; Blinkin; blinkin, bub-linking kinetochore protein; Bub-linking kinetochore protein; cancer susceptibility candidate 5; Cancer susceptibility candidate gene 5 protein; Cancer susceptibility candidate gene 5 protein homolog; Cancer/testis antigen 29; CT29; D40; kinetochore null 1 homolog; Kinetochore scaffold 1; Kinetochore-null protein 1; microcephaly, primary autosomal recessive 4; Outer kinetochore KNL1 complex subunit KNL1; Protein CASC5; Protein D40/AF15q14; protein phosphatase 1, regulatory subunit 55; RAD51 homolog
Gene Aliases: 2310043D08Rik; 5730505K17Rik; AF15Q14; CASC5; CT29; D40; hKNL-1; hSpc105; KIAA1570; KNL1; MCPH4; PPP1R55; Rad51; Spc7
UniProt ID: (Mouse) Q66JQ7, (Human) Q8NG31
Entrez Gene ID: (Mouse) 76464, (Rat) 311327, (Human) 57082
cell cycle
chromosome segregation
mitotic nuclear division
attachment of spindle microtubules to kinetochore
negative regulation of phosphatase activity
protein localization to kinetochore
cell division
spindle assembly checkpoint
mitotic sister chromatid segregation
acrosome assembly
homologous chromosome orientation involved in meiotic metaphase I plate congression
regulation of mitotic cell cycle spindle assembly checkpoint
positive regulation of meiosis I spindle assembly checkpoint
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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