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CASK Polyclonal Antibody
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FIGURE: 1 / 1
CASK Antibody (BS-11338R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Rat Brain; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with CASK/CAMGUK Polyclonal Antibody, Unconjugated (bs-11338R) at 1:200 overnight at 4°C, followed by a conjugated secondary and DAB staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
BS-11338R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CASK, amino acids 651-750.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CASK is a calcium/calmodulin-dependent serine protein kinase which is a MAGUK (membrane-associated guanylate kinase) protein family member. CASK is a scaffold protein and the encoded protein is located at synapses in the brain. CASK associates with FG syndrome 4, mental retardation, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. CASK functions as a cytoskeletal membrane scaffold that coordinates signal transduction pathways within the cortical cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium/calmodulin-dependent serin protein kinase; calcium/calmodulin-dependent serine protein kinase (MAGUK family); calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase; CAMGUK protein; CASK; membrane associated guanylate kinase; MGC7449; OTTHUMP00000023157; OTTHUMP00000023161; OTTHUMP00000023162; peripheral plasma membrane protein CASK-like; protein lin-2 homolog; RP23-278L4.1; trinucleotide repeat containing 8; unnamed protein product
Gene Aliases: CAGH39; CAMGUK; CMG; DXPri1; DXRib1; FGS4; hCASK; LIN-2; LIN2; MICPCH; mLin-2; MRXSNA; Pals3; TNRC8
UniProt ID: (Human) O14936, (Mouse) O70589, (Rat) Q62915
Entrez Gene ID: (Human) 8573, (Mouse) 12361, (Rat) 29647
negative regulation of cell-matrix adhesion
regulation of transcription from RNA polymerase II promoter
protein localization
negative regulation of keratinocyte proliferation
protein transport
positive regulation of insulin secretion
positive regulation of transcription from RNA polymerase II promoter
regulation of neurotransmitter secretion
positive regulation of transport
positive regulation of dendritic spine morphogenesis
negative regulation of wound healing
calcium ion import
protein localization to plasma membrane
positive regulation of calcium ion import
negative regulation of cellular response to growth factor stimulus
regulation of synaptic vesicle exocytosis
cell adhesion
GMP metabolic process
GDP metabolic process
cerebral cortex development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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