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Product Details
PA1-25080
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:300 | - |
Immunoprecipitation (IP) |
5-10 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Dog, Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide, conjugated to KLH, corresponding to residues K(393) S S P Q I R N P P S D A V Q R A(409) of human CASK. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
0.01M PBS, pH 7.4, with 1% BSA |
Contains |
15mM sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2068734 |
Product Specific Information
Recommended positive controls: Jurkat, MDCK.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium/calmodulin-dependent serin protein kinase; Calcium/calmodulin-dependent serine protein kinase; calcium/calmodulin-dependent serine protein kinase (MAGUK family); calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase; G-protein-coupled receptor GPR34; hCASK; MGC7449; OTTHUMP00000023157; OTTHUMP00000023161; OTTHUMP00000023162; Peripheral plasma membrane protein CASK; Protein lin-2 homolog; RP23-278L4.1; trinucleotide repeat containing 8
Gene Aliases: CAGH39; CAMGUK; CASK; CMG; FGS4; LIN2; MICPCH; MRXSNA; TNRC8
UniProt ID: (Human) O14936
Entrez Gene ID: (Dog) 480887, (Human) 8573
Molecular Function:
scaffold/adaptor protein
negative regulation of cell-matrix adhesion
protein phosphorylation
cell adhesion
neurotransmitter secretion
negative regulation of keratinocyte proliferation
positive regulation of transcription from RNA polymerase II promoter
GMP metabolic process
GDP metabolic process
negative regulation of wound healing
calcium ion import
positive regulation of calcium ion import
negative regulation of cellular response to growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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