Immunogen sequence: AYKIHLPETV EQLRKFNARR KLKGAVLAAV SSHKFNSFYG DPPEELPDFS EDPTSSGAVS QVLDSLEEIH ALTDCSEKDL DFLHSVFQDQ HLHTLLDLYD KINTKSSPQI RNPPSDAVQR AKEVLEEISC YPENNDAKE
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 96%.
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The calcium/calmodulin-dependent kinase (CAMK) group consists of 75 kinases regulated by Ca2+/CaM and close relative family (CAMK, CAMKL, DAPK, MAPKAPK).
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Protein Aliases: calcium/calmodulin-dependent serin protein kinase; Calcium/calmodulin-dependent serine protein kinase; calcium/calmodulin-dependent serine protein kinase (MAGUK family); calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase; hCASK; OTTHUMP00000023157; OTTHUMP00000023161; OTTHUMP00000023162; Peripheral plasma membrane protein CASK; Protein lin-2 homolog; trinucleotide repeat containing 8
Gene Aliases: CAGH39; CAMGUK; CASK; CMG; FGS4; LIN2; MICPCH; MRXSNA; TNRC8
UniProt ID: (Human) O14936
Entrez Gene ID: (Human) 8573