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Invitrogen
CASK Polyclonal Antibody
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FIGURE: 1 / 4
CASK Antibody (PA5-85785) in ICC/IF
CASK Polyclonal Antibody detects CASK protein by immunofluorescent analysis. Sample: DIV14 rat E18 primary cortical neurons were fixed in 4% paraformaldehyde at RT for 15 min. Green: CASK protein stained by CASK Polyclonal Antibody (Product # PA5-85785) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody [GT1338] diluted at 1:500. Blue: Fluoroshield with DAPI .
Product Details
PA5-85785
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of mouse CASK. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.77 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (92%), Rhesus Monkey (93%), Bovine (93%).
Positive Control: mouse brain, rat brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CASK is a calcium/calmodulin-dependent serine protein kinase which is a MAGUK (membrane-associated guanylate kinase) protein family member. CASK is a scaffold protein and the encoded protein is located at synapses in the brain. CASK associates with FG syndrome 4, mental retardation, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. CASK functions as a cytoskeletal membrane scaffold that coordinates signal transduction pathways within the cortical cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium/calmodulin-dependent serine protein kinase; MGC7449; OTTHUMP00000023157; OTTHUMP00000023161; OTTHUMP00000023162; Peripheral plasma membrane protein CASK; RP23-278L4.1
Gene Aliases: Cask; DXPri1; DXRib1; LIN-2; mLin-2; Pals3
UniProt ID: (Rat) Q62915, (Mouse) O70589
Entrez Gene ID: (Rat) 29647, (Mouse) 12361
transcription coactivator activity
calmodulin-dependent protein kinase activity
G-protein coupled receptor activity
protein binding
calmodulin binding
ATP binding
protein C-terminus binding
PDZ domain binding
protein complex binding
neurexin family protein binding
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
scaffold/adaptor protein
negative regulation of cell-matrix adhesion
protein complex assembly
protein phosphorylation
intracellular protein transport
G-protein coupled receptor signaling pathway
negative regulation of keratinocyte proliferation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of wound healing
calcium ion import
positive regulation of calcium ion import
negative regulation of cellular response to growth factor stimulus
regulation of nucleic acid-templated transcription
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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