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CASPR/Neurexin4 Polyclonal Antibody
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Product Details
BS-11128R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CASPR/Neurexin4, amino acids 151-250.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CNTNAP1 was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. The gene product was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 381-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Caspr; caspr1; contactin associated protein 1; Contactin-associated protein 1; MHDNIV; NCP1; neurexin 4; neurexin 4 (contactin associated protein); Neurexin IV; Neurexin-4; p190; Paranodin
Gene Aliases: AI841080; CASPR; CHN3; CNTNAP; CNTNAP1; NCP1; NRXN4; P190; shm
UniProt ID: (Human) P78357, (Rat) P97846, (Mouse) O54991
Entrez Gene ID: (Human) 8506, (Rat) 84008, (Mouse) 53321
protein localization to paranode region of axon
cytoskeleton organization
cell adhesion
axo-dendritic transport
neuronal action potential propagation
paranodal junction assembly
neuron projection development
myelination
neuron projection morphogenesis
neuromuscular process controlling posture
neuromuscular process controlling balance
mitochondrion organization
signal transduction
axonogenesis
central nervous system development
central nervous system myelination
myelination in peripheral nervous system
neuromuscular process
protein localization to juxtaparanode region of axon
regulation of synapse maturation
postsynaptic density organization
neuromuscular junction development, skeletal muscle fiber
paranodal junction maintenance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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