The antibody detects endogenous levels of total CATSPER1 protein.
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cation channel sperm-associated protein 1; cation channel, sperm associated 1; CatSper1; hCatSper; sperm ion channel; sperm-associated cation channel 1
Gene Aliases: CATSPER; CATSPER1; SPGF7
UniProt ID: (Human) Q8NEC5
Entrez Gene ID: (Human) 117144