Immunogen sequence: DSVLNIPAPL HPETTVNMTY QPTTPSSSFQ DVSVFGMDAG SPLVVPPPTD SARLLNTSPK VPDKNTCPSG IPKPVFTHSK DTPSSQEGME NYQV
Highest antigen sequence identity to the following orthologs: Mouse - 61%, Rat - 62%.
CAZIP, also known as TIP150, contains a leucine-zipper domain at the C-terminus and has at least three isoforms. CAZIP is expressed in heart during early cardiac development and in parts of the nervous system in later embryonic development. It is thought to bind microtubules and facilitate the end-binding protein 1 (EB1)-dependent loading of MCAK onto microtubules plus ends and orchestrates the dynamics at the plus end of microtubules. CAZIP may regulate the dynamics of microtubules at their growing distal tip.
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Protein Aliases: +TIP of 150 kDa; Cardiac zipper protein; Microtubule plus-end tracking protein TIP150; Microtubule-associated tumor suppressor candidate 2; RP11-274A8.2; Tracking protein of 150 kDa
Gene Aliases: CAZIP; ICIS; KIAA0774; MTUS2; TIP150
UniProt ID: (Human) Q5JR59
Entrez Gene ID: (Human) 23281