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Product Details
H00000863-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CBFA2T3 (AAH62624.1, 1 a.a. approximately 615 a.a) full-length human protein.
Conjugate
Unconjugated
Form
Liquid
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MPASRLRDRA ASSASGSTCG SMSQTHPVLE SGLLASAGCS APRGPRKGGP APVDRKAKAS AMPDSPAEVK TQPRSTPPSM PPPPPAASQG ATRPPSFTPH TLMNGSSHSP TAINGAPCTP NGFSNGPATS STASLSTQHL PPACGARQLS KLKRFLTTLQ QFGSDISPEI GERVRTLVLG LVNSTLTIEE FHSKLQEATN FPLRPFVIPF LKANLPLLQR ELLHCARLAK QTPAQYLAQH EQLLLDASAS SPIDSSELLL EVNENGKRRT PDRTKENGSD RDPLHPQRYS PSNGPPQPTP PPHYRLEDIA MAHHFRDAYR HPDPRELRER HRPLVVPGSR QEEVIDHKLT EREWAEEWKH LNNLLNCIMD MVEKTRRSLT VLRRCQEADR EELNHWARRY SDAEDTKKGP APAAARPRSS SAGPEGPQLD VPREFLPRTL TGYVPEDIWR KAEEAVNEVK RQAMSELQKA VSDAERKAHE LITTERAKME RALAEAKRQA SEDALTVINQ QEDSSESCWN CGRKASETCS GCNAARYCGS FCQHRDWEKH HHVCGQSLQG PTAVVADPVP GPPEAAHSLG PSLPVGAASP SEAGSAGPSR PGSPSPPGPL DTVPR
Target Information
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: core-binding factor, runt domain, alpha subunit 2; translocated to, 3; hMTG16; MTG16HEL; MTG8-related gene 2; MTG8-related protein 2; myeloid translocation gene 8 and 16b; Myeloid translocation gene on chromosome 16 protein; Protein CBFA2T3; Zinc finger MYND domain-containing protein 4
Gene Aliases: CBFA2T3; ETO2; MTG16; MTGR2; RUNX1T3; ZMYND4
UniProt ID: (Human) O75081
Entrez Gene ID: (Human) 863
response to hypoxia
transcription, DNA-templated
cell proliferation
negative regulation of cell proliferation
granulocyte differentiation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
regulation of aerobic respiration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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